Venous Thrombosis

Venous thrombosis can be divided into deep vein thrombosis and superficial vein thrombosis according to the location of thrombosis. Deep vein thrombosis refers to the disease caused by abnormal clotting of blood in deep veins. It usually occurs in the lower extremities and may cause a pulmonary embolism. Superficial vein thrombosis is mostly a clinical manifestation of thrombotic superficial phlebitis, and it often occurs in varicose veins. The elderly not only have a high incidence, but are also prone to fatal pulmonary embolism, which deserves more attention. Venous thrombosis is a multifactorial disease caused by a variety of risk factors, such as genetics, environment, and behavior.

Diagnosis of Venous Thrombosis

The diagnosis methods of venous thrombosis are as follows:

• Physical examination. Deep vein thrombosis can be seen with swelling of limbs and distal superficial varicose veins, etc. Deep vein thrombosis can be found locally with nodular tenderness.
• Blood test. When thrombosis occurs in the deep veins of the lower extremities, it can be manifested as an increase in the concentration of D-dimer in the blood. However, in some other clinical situations, such as after surgery, pregnant women, critically ill or malignant tumors, the blood D-dimer may also be increased. Therefore, the D-dimer test has high sensitivity but poor specificity, and further tests are needed to diagnose the disease.
• Imaging diagnosis. Including radionuclide examination, CT venography, ultrasound examination and so on. Among them, CT venography is the gold standard for diagnosing venous thrombosis, but it is harmful to the body. Ultrasonography has gradually replaced venography in clinical practice.
• Genetic diagnosis. The G1691A mutation in the human gene encoding human coagulation factor V is a major risk factor for venous thrombosis, and the detection of this mutation gene can help in diagnosis.

Advantages of Our Products

Creative Biogene's venous thrombosis diagnostic products are mainly targeted at genetic diagnosis and using PCR or real-time PCR analysis mode. The kit is used to detect the mutations most commonly associated with thrombosis by allele-specific reverse hybridization. Our products are of excellent quality, with good accuracy, reproducibility and stability, making them the best choice for your research.

Creative Biogene’s skilled scientists have experience in developing outstanding products in the field of venous thrombosis diagnosis. Our products are competitive in the market due to their reasonable price and high quality, which can help you solve the diagnosis problem quickly. You can choose us with confidence.

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Reference

1. Favaloro E J. (2019). "Genetic testing for thrombophilia-related genes: observations of testing patterns for factor V Leiden (G1691A) and prothrombin gene “Mutation”(G20210A)." Seminars in thrombosis and hemostasis. 45.7: 730-743