Neurodegenerative Diseases

Neurodegeneration refers to the progressive structural and functional loss of neurons, leading to heterogeneous clinical and pathological manifestations, followed by deterioration of functional anatomy. Neurodegenerative diseases occur when nerve cells in the brain or peripheral nervous system lose function over time and eventually die. Degenerative neurological diseases include Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, and so on. Degenerative neurological diseases affect many activities of the body, such as balance, movement, speech, breathing, and heart function. Many of these diseases are inherited. Sometimes the cause may be medical conditions such as alcoholism, tumor, or stroke. Other causes may include toxins, chemicals, and viruses.

Diagnosis of Neurodegenerative Diseases

The focus of current research on neurodegenerative diseases is to establish detectable biomarkers from blood or saliva to distinguish different forms of neuronal diseases. The earliest sign of Alzheimer's disease observed with fluorodeoxyglucose-PET is metabolic decline. Metabolomics, the detection and identification of small molecular metabolites in biological samples, is a new frontier approach in the diagnosis of neurodegenaration associated metabolic disorders. Genetic markers associated with familiar neurodegenerative diseases have been identified for different types of disease, such as the diagnosis of amyloid precursor protein in Alzheimer's disease, mutations in the presenilin gene, and apolipoprotein E (APOE) polymorphism are some known genetic markers, while for Parkinson's disease, α-synuclein protein or PrP gene mutation for the familiar type of prion diseases, etc. have been identified, although their sensitivity and specificity remain questionable.

Advantages of Our Products

Creative Biogene's test kits quantitatively measure β-amyloid in human cerebrospinal fluid through immunoassay methods, and they are designed to help patients with Alzheimer's disease and other cognitive disorders patients to assess for cognitive decline. Our products are simple and convenient to operate, can quickly obtain accurate detection results, and have high sensitivity and specificity. It is the best choice for your related research.

Creative Biogene focuses on the research and development of neurodegenerative diseases diagnostic products. After years of unremitting efforts, we have become experts in the diagnostic field. We are committed to providing customers with the best products to help you quickly solve the problems in diagnostic research. We look forward to working with you for your cooperation.

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Reference

1. Poddar K, et al. (2021) Apala Chakraborty, and Soumyabrata Banerjee. "Neurodegeneration: Diagnosis, Prevention, and Therapy." Oxidoreductase. IntechOpen.