Stroke

A stroke occurs when blood vessels in the brain rupture and bleed, or when the blood supply to the brain is blocked. The rupture or blockage will prevent blood and oxygen from reaching the brain tissue. When there is no oxygen, brain cells and tissues are damaged and begin to die within a few minutes. According to the Centers for Disease Control and Prevention (CDC), stroke is the fifth leading cause of death in the United States. Every year, more than 795,000 Americans have a stroke. Loss of blood flow to the brain damages the tissue in the brain. The symptoms of stroke appear in body parts controlled by damaged areas of the brain, manifested as paralysis, trouble speaking or understanding speech, confusion, vision problems, trouble walking, loss of balance or coordination, numbness or weakness in the arm, face, and leg, especially on one side of the body, etc. The earlier stroke patients get care, the better their chances of recovery are.

Diagnosis of Stroke

miR-210 represents the main hypoxia-induced miRNA, also known as hypoxapyrimidine, which is commonly expressed in a wide range of cells. Emerging evidence suggests that the induction of miR-210-3p is a consistent feature of the hypoxia response of normal and malignant cells. miR-210 is related to a variety of important targets such as cancer, cell cycle regulation, cell survival, differentiation, metabolism, and angiogenesis. The level of miRNA-210 in the blood of stroke patients is significantly reduced, and the level of stroke patients with a good prognosis is significantly higher than that of patients with a poor prognosis. miR-451a is a miRNA associated with cell metabolism. miR-451a has been identified as a biomarker for the pathogenesis and prognosis of patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA).

Advantages of Our Products

Creative Biogene's test kit mainly uses enzyme immunoassay to detect whether the levels of miR-210 and miR-451a in the body are normal to help diagnose stroke. Our products are simple and convenient to operate, and have excellent performance in sensitivity, specificity and accuracy, which can help you to carry out related research smoothly.

Creative Biogene skilled scientists have extensive experience in developing diagnostic products for stroke. It is sincerely looking forward to cooperating with you and providing you with the best quality product with all of our hearts! You can choose us without hesitation.

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Reference

1. Wang W, et al. (2014). "Circulating MicroRNAs as Novel Potential Biomarkers for Early Diagnosis of Acute Stroke in Humans." J Stroke Cerebrovasc Dis. 23.10:2607-2613.