Endocrine Disease

Endocrine diseases are mainly caused by abnormalities in the secretory function and structure of endocrine glands and endocrine tissues. It also includes abnormal sources of hormones, abnormal hormone receptors, as well as physiological disorders caused by abnormal metabolism of substances. In terms of classification, it mainly shows the dysfunction of endocrine glands, including hyperfunction and hypofunction. In addition, normal function but abnormal glandular tissue structure can also cause endocrine diseases. Common endocrine diseases include diabetes, Cushing's disease, Edison's disease and thyroid disease, etc. In general, it is necessary to make a clear diagnosis for this type of disease, and then standardize treatment.

Diagnosis Method

Common diagnostic methods for endocrine diseases:

• Hormone concentration test. The concentration of hormones in body fluids can be determined by radioimmunoassay, enzyme-linked immunoassay, and other methods. The reliability of the antibody determines the purity, characteristics, and quality of the sample.
• Hormone dynamic observation. Measure the normal rhythm of hormone secretion, such as ACTH, circadian fluctuation of cortisol, etc. The disappearance of normal rhythm is mostly an early manifestation of abnormal glandular function.
• Hormone regulation function test. Including the excitement test and the inhibition test, it is of great significance in identifying physiological changes and clarifying the nature of pathological changes.
• Receptor test. The quantitative and qualitative determination of various target cell receptors, such as erythrocyte insulin receptors.
• Target cell function test. Only the response of target cells can reflect the abnormal function of the endocrine glands clinically, so measuring the function of target cells can objectively evaluate the effects of hormones.
• Imaging test. Identify endocrine gland tumors, and early detection of distant metastases of carcinoma.
• Pathological examination. Determine the nature of the lesion.

Diagnosis Products of Endocrine Disease

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Reference

1. Bancos I, et al. (2016). "Diagnosis of endocrine disease: The Diagnostic performance of adrenal biopsy: A Systematic Review and Meta-Analysis." European Journal of Endocrinology. 175.2: R65.