Herpes

Herpes refers to the human herpesvirus (HHV) infection caused by changes in the skin and mucous membranes. Herpes is mainly manifested as single or clustered blisters, and sometimes pustules. It may be accompanied by itching, fever, pain and local lymph node enlargement, etc. Most patients can develop clinical symptoms after infection, and then the virus is dormant in the human body. When a certain inducement such as fever or trauma occurs, the virus can be activated and cause herpes to recur. Clinical common herpes includes herpes simplex, chickenpox and herpes zoster and other diseases.

Diagnosis of Herpes

Most of the herpes can be diagnosed based on clinical manifestations, medical history and physical signs, etc., but related laboratory tests will be done under atypical symptoms or in some special cases.

Chickenpox and zoster virus tests:

• Antigen test. The diagnosis can be made directly by direct immunofluorescence, enzyme-free staining or ELISA to detect the antigens in the herpes basal cell scratch or herpes fluid.
• ELISA method to detect IgM antibodies. The incubation period of chickenpox is generally about 2 weeks. When the rash occurs, IgM antibodies in the blood have been produced. IgM antibodies can be maintained for about 2 months, and the detection of IgM antibodies can help establish a diagnosis. This method has strong specificity sensitivity. Herpes zoster is a recurrent infection, IgM antibody titer is low, 70% of the disease can be detected by radioimmunoassay.

Herpes simplex virus tests:

• Immunofluorescence or enzyme staining for antigens test. It is used for cell smears such as cervical exfoliated cells, corneal scraping cells, and ulcer bottom scraping cells. Direct immunofluorescence or enzyme immunostaining is used for antigen detection. A positive result indicates infection.
• Double antibody sandwich ELISA to detect antigen. It is mainly used to detect HSV antigen in cerebrospinal fluid. It can also be used to detect HSV antigen in patients' herpes fluid, ulcer bottom scraping and biopsy tissue.

Advantages of Our Products

Most of Creative Biogene's herpes test kits use immunoassay methods to qualitatively detect and distinguish antibodies against herpes virus in human serum, plasma or whole blood. Our products can be tested at any time without special sample preparation. They are stored at room temperature, easy to transport, and accurate results can be obtained in a short time, helping your research to develop smoothly.

Creative Bioarray focuses on the field of diagnostic reagents for herpes. We are committed to providing the best products to accelerate the realization of customers' research goals. We look forward to working with you for your cooperation.

Please contact us for more details.

Reference

1. Fatahzadeh M and Robert A. (2007). "Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis, and management." Journal of the American Academy of Dermatology. 57.5: 737-763.