Cystic Fibrosis

Cystic fibrosis is a hereditary exocrine gland disease that may affect many parts of the body, of which the lungs and digestive system are the most severely affected. It is usually characterized by chronic obstructive pulmonary disease, persistent respiratory infection, pancreatic exocrine dysfunction, malnutrition, and abnormally elevated sweat electrolytes. Cystic fibrosis is an autosomal recessive genetic disease caused by mutations in the CF gene on the seventh chromosome, which affects the movement of salt and water inside and outside the cell. The disease prevalence is estimated to be 1 in 2,500 to 4,000 newborns. At present, there is no effective treatment for cystic fibrosis, but some methods can alleviate complications and improve the quality of life. The prenatal genetic test can also prevent cystic fibrosis to a certain extent.

Diagnosis of Cystic Fibrosis

The relevant diagnosis methods for cystic fibrosis are as follows:

• Imaging examination. Different stages of the disease can be manifested on X-rays as darkened or scattered circles, small patches of fuzzy inflammation in the bronchial texture of both lungs. Localized collapse, bronchiectasis, and pulmonary abscess can also be observed.
• Marker detection. Check the chemical substance released by the pancreas in the blood sample. This chemical substance is immunoreactive trypsinogen (IRT). The patient's IRT level is higher than normal, but additional tests are required to determine cystic fibrosis.
• Sweat test. Measure the salt content of sweat, which can be abnormally high in people with cystic fibrosis.
• Genetic test. Check blood or saliva samples for the wrong gene that causes cystic fibrosis. The genetic test can also be used to determine whether someone is a "carrier" of cystic fibrosis in the case of illness in the family.

Advantages of Our Products

Creative Biogene's cystic fibrosis products are primarily kits for the genetic test, which can simultaneously detect all mutations and variants recommended for cystic fibrosis vector screening. Highly accurate and reproducible sequencing technology delivers dependable results. Using our products, you can get results simply, quickly and efficiently.

Creative Biogene's skilled scientists have extensive experience in developing diagnostic products for cystic fibrosis. It is sincerely looking forward to cooperating with you and providing you the best quality product with all of our hearts! You can choose us without hesitation.

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Reference

1. Straniero L, et al. (2016). "Whole-gene CFTR sequencing combined with digital RT-PCR improves genetic diagnosis of cystic fibrosis." Journal of human genetics. 61.12: 977-984.