Whooping Cough

Whooping cough (Pertussis) is an acute respiratory infectious disease caused by Bordetella pertussis. The course of the disease is several months. After the invasion of Bordetella pertussis into the respiratory, it reproduces and releases endotoxins in the cilia of the respiratory, causing inflammation. The symptoms of the patient are dyspnea, paroxysmal spastic cough, and accompanied by deep "cock-crow" inspiratory roar, which may be complicated by pneumonia, neurological diseases, etc. In severe cases, it can also cause death. Whooping cough is very contagious, but vaccination can effectively prevent the disease. Infants and young children are a high incidence of whooping cough, and the incidence of infants younger than 6 months is higher than that of other age groups.

Diagnosis of Whooping Cough Infection

The following methods can assist in the diagnosis of whooping cough:

• Blood test. Peripheral blood white blood cell count and lymphocyte classification are significantly increased. The absolute lymphocyte count is often greater than or equal to 10000 pl, and the significant increase in the number of white blood cells is related to the severity of whooping cough. Neutrophils can also increase during secondary infection.
• Serum test. It is mainly used for retrospective diagnosis and epidemiological research, such as the ELISA method to detect pertussis exotoxin antibody.
• Etiological examination. Polymerase chain reaction detects the DNA of Bacillus pertussis in nasopharyngeal secretions of patients, or directly cultivates B. pertussis in nasopharyngeal secretions through bacterial culture, and the positive rate of catarrhal phase is high.
• Imaging examination. When pneumonia is associated with whooping cough, X-rays are used to check for inflammation or fluid accumulation in the lungs.

Advantages of Our Products

Creative Biogene's whooping cough diagnostic products are mainly detection kits, which take the highly conserved region of the B. pertussis genome as the target area, design specific primers and fluorescent probes, and perform PCR amplification to ensure the accuracy of the product. Product performance is superior, with rapid, sensitive, specific diagnostic value.

Creative Biogene focuses on the field of diagnostic reagents for whooping cough. We are committed to providing the best products to accelerate the realization of customers' research goals. Our products are competitive in the market due to their reasonable price and high quality. You can choose us with confidence.

Please contact us for more details.

Reference

1. Martini H, et al. (2017). "Improving specificity of Bordetella pertussis detection using a four-target real-time PCR." PLoS One. 12.4: e0175587.