Leptospirosis

Leptospirosis is an acute zoonotic infectious disease caused by pathogenic Leptospira. The main manifestations are blood emia in the early stage, various organ damage and dysfunction in the middle stage, and various allergic symptoms in the late stage. In severe cases, there are obvious liver, kidney, central nervous system damage and diffuse lung bleeding, even life-threatening. Rodents and pigs are the main host and source of infection. They are mainly spread through contact with animal excrement containing Leptospira or their contaminated water, including infection by eating food and water contaminated by rat urine. Infection after rat and dog bites has also been reported, with general human susceptibility.

Diagnosis of Leptospirosis

The following methods can be used to detect leptospirosis:

Physical examination. Including superficial lymph node examination, skin and mucous membrane examination, lung physical examination, abdominal physical examination, cardiac examination, nervous system examination, etc.

Blood routine. The leucocytes and neutrophils increased slightly.

Urine routine. There is proteinuria. Red blood cells and white blood cells are also visible under a microscope.

Immune test. Leptospira-specific antibodies are tested by micro-agglutination test and ELISA method, and they are usually positive one week after the illness.

Blood culture. Blood samples are collected within one week after the onset of the disease, and inoculated in Korotkoff medium. Under appropriate conditions, Leptospira can be cultured.

Cerebrospinal fluid examination. Patients with meningitis will experience increased cerebrospinal fluid pressure, increased protein, and decreased white blood cells.

Imaging tests. X-ray is the main form. In patients with pulmonary hemorrhagic blood type, ground-glass or diffuse spot/sheet or fused sheet opacity can be seen in both lungs on X-ray.

Advantages of Our Products

Creative Biogene's test kits use immunochromatography, ELISA, and other methods to qualitatively detect Leptospira-specific antibodies in human plasma, serum or whole blood. Our products have the advantages of strong sensitivity, high accuracy, good reproducibility, simple and convenient operation, which will help your related research to be carried out smoothly.

Creative Biogene focuses on the research and development of leptospirosis diagnostic products. After years of unremitting efforts, we have become experts in the diagnostic field. We are committed to providing customers with the best products to help you quickly solve the problems in diagnostic research. We look forward to working with you for your cooperation.

Please contact us for more details.

Reference

1. Sykes J E, et al.(2010). "2010 ACVIM Small Animal Consensus Statement on Leptospirosis: Diagnosis, Epidemiology, Treatment, and Prevention." Journal of Veterinary Internal Medicine. 25.1:1-13.