Chikungunya Fever

Chikungunya is caused by Chikungunya virus (CHIKV). It is an acute infectious disease characterized by fever, rash, and joint pain, but usually not fatal. Chikungunya epidemic was first confirmed in Tanzania in 1952, and the virus was isolated in 1956. The disease is mainly prevalent in Africa and Southeast Asia, and has caused a large-scale epidemic in the Indian Ocean in recent years. Aedes aegypti and Aedes albopictus are the main vectors of this disease, which are mainly transmitted through the bite of the infected Aedes mosquito. There are no reports of direct human-to-human transmission.

Diagnosis of Chikungunya Fever

There are several ways to test chikungunya fever:

• Blood routine test. The white blood cell count is often normal. The total white blood cell count, lymphocytopenia, and platelet are slightly decreased in a few patients.
• Biochemical test. Some patients have elevated serum ALT, AST, and creatine kinase (CK).
• Cerebrospinal fluid test. The cerebrospinal fluid test in patients with meningoencephalitis is consistent with the changes of viral injury.
• Serological test. Serum-specific IgM antibodies are detected by ELISA, immunochromatography and other methods. The results of the capture method to detect IgM antibodies are reliable. Serum-specific IgG antibodies are detected by ELISA, immunofluorescence antibody determination, immunochromatography, and other methods.
• Nucleic acid test. Use RT-PCR and Real-time PCR and other nucleic acid amplification methods to test the virus. Generally, the viral nucleic acid can be detected in the patient's serum within 4 days after the onset of the disease.
• Virus isolation. Serum samples from patients within 2 days of onset of illness were collected, and sensitive cells such as Vero, C6/36, BHK-21, and HeLa are used for virus isolation.

Advantages of Our Products

Creative Biogene's test kit uses the aforementioned real-time PCR, RT-PCR, ELISA, and other immunoassay methods to test and analyze the CHIKV virus so as to diagnose chikungunya fever. Our products have the advantages of high sensitivity, strong specificity, fast detection speed, simple and convenient operation, all of which will be available to expedite your research.

Creative Biogene focuses on the research and development of chikungunya fever diagnostic products. After years of unremitting efforts, we have become experts in the diagnostic field. We are committed to providing customers with the best products to help you quickly solve the problems in diagnostic research. We look forward to working with you for your cooperation.

Please contact us for more details.

Reference

1. Mohan A, et al. (2010). Epidemiology, clinical manifestations, and diagnosis of Chikungunya fever: lessons learned from the re-emerging epidemic. Indian journal of dermatology. 55.1: 54.