Poliomyelitis

Poliomyelitis, also known as polio, is an acute infectious disease caused by poliovirus and is highly contagious. Humans are the only known natural host of poliovirus. The fecal-oral route is the main route of transmission. The virus enters the intestinal tract through the mouth and reproduces in the intestinal tract. 90%-95% of poliomyelitis is a recessive infection, that is, there are no symptoms. Some patients may have a fever, headache, sore throat, fatigue and so on. In addition, because the poliovirus can invade the nervous system, patients can also experience flaccid paralysis, and severe cases can die due to respiratory muscle paralysis. The disease lacks effective treatment methods, and vaccination to prevent infection is the key.

Diagnosis of Poliomyelitis

There are several methods to detect poliomyelitis:

• Blood routine. The total number of white blood cells and the percentage of neutrophils are mostly normal.
• Virus isolation. Isolate poliovirus from the pharynx or feces, and then use sequencing analysis or specific antiserum neutralization test to identify its serotype. This test method is the most important confirmatory test for this disease.
• Serum immunological examination. ELISA method is used to detect the anti-poliovirus IgM antibody in the blood and cerebrospinal fluid of patients, which can help early diagnosis. The IgG antibody titer in the serum of convalescent patients is more than 4 times higher than that in the acute phase, which is of diagnostic significance.
• Cerebrospinal fluid test. There are differences in the results of cerebrospinal fluid examinations in different periods. In the pre-paralysis and early stages of paralysis, the number of cells (mainly lymphocytes) can be seen, and the increase in protein is not obvious, showing the phenomenon of cell protein separation, which has a certain reference value for diagnosis. At the third week of paralysis, the number of cells had returned to normal, while the protein level continued to increase.

Advantages of Our Products

Creative Biogene's poliomyelitis diagnostic products are mainly carried out by directly detecting the infectious agent in the feces or throat wash during the virus incubation period, or by identifying the antibodies in the blood. In this test, the titers of the paired sera relative to the three types of viruses are measured separately. Using the ELISA method, can simultaneously detect antibodies against the three types of poliomyelitis. Our products have the advantages of fast, efficient and accurate.

Creative Biogene has a professional team of experts who developed quality poliomyelitis diagnostic products. Our products are competitive in the market due to their reasonable price and high quality, which can help you solve the diagnosis problem quickly. We look forward to working with you for your cooperation.

Please contact us for more details.

Reference

1. Ditunno J, et al. (2016). "Franklin Delano Roosevelt: the diagnosis of poliomyelitis revisited." PM & R: the journal of injury, function, and rehabilitation. 8.9: 883-893.