Vasculitis

Vasculitis refers to autoimmune diseases caused by various reasons, with inflammation of fibrinoid necrosis in the blood vessel wall or perivascular tissues as the main characteristics. The clinical symptoms of patients vary according to the type, size, location, and pathological characteristics of the affected vessels, including systemic symptoms such as fever, night sweats, and fatigue, as well as local symptoms such as pathological vascular ischemia and corresponding organ dysfunction. When there are significant systemic manifestations that multiple systems are involved, it is also called systemic vasculitis. The etiology of vasculitis is complex, including genetics, endocrine, infection, tumor, chronic inflammatory diseases, drugs, environment, etc. The pathogenesis is unknown, and it may be that the pathogenic factors directly destroy the vessel wall, or that the immune mediator leads to the vascular wall to produce the inflammatory response.

Diagnosis of Vasculitis

The examination methods for vasculitis include the following:

• Blood routine. The patient will have elevated white blood cells, but no significant changes in neutrophils, and non-specific blood abnormalities such as increased platelets.
• Serum protein detection. Patients will have non-specific α1 globulin, α2 globulin, and γ globulin elevations, active inflammation, and require treatments.
• Autoantibody detection. Including anti-nuclear antibody (ANA), anti-neutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane (GBM) antibody, which are helpful for the diagnosis and differential diagnosis of vasculitis.
• Imaging diagnosis. Including X-ray, CT, MRI, PET, angiography and Doppler ultrasound. These tests can help determine which blood vessels and organs are affected, and monitor the effectiveness of treatment.
• Pathological examination. If conditions permit, a puncture biopsy of the involved organs can be performed, and a positive result of the pathological examination is of great significance for the diagnosis of vasculitis.

Advantages of Our Products

Creative Biogene's products are mainly for the detection of breeding antibodies to diagnose vasculitis, and use enzyme-linked immunoassay to qualitatively and quantitatively determine the IgG antibody of GBM, CIC-C3d, etc. in human serum or plasma. Our product can quickly detect autoantibodies produced when vasculitis occurs, and is one of the effective methods for vasculitis detection. The advantages of our products are simple operation, accurate detection results, sensitivity and specificity.

Creative Biogene is an expert in the field of vasculitis diagnosis. It is sincerely looking forward to cooperating with you and providing you the best quality product with all of our hearts! You can choose us without hesitation.

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Reference

1. Damoiseaux J, et al. (2010). "Evaluation of the FIDIS Vasculitis Multiplex Immunoassay for Diagnosis and Follow-up of ANCA-Associated Vasculitis and Goodpasture's Disease." Annals of the New York Academy of Sciences. 1109:454-463.