Nephritis

Glomerulonephritis, referred to as nephritis, is a group of immune-mediated and involved in inflammatory mediators (such as complement, cytokines, reactive oxygen species, etc.) that eventually lead to inflammatory changes in the inherent renal tissues and cause varying degrees of renal dysfunction diseases. It is not a single disease, but a group of diseases caused by multiple etiologies and pathogenesis, with different pathological types, and often overlapping clinical manifestations. The patient’s glomerular morphology and (or) function is damaged, with the following characteristics: glomerular changes in the permeability of proteins and cells, impaired kidney ability to regulate water, electrolytes, acid-base balance and blood pressure, and glomerular filtration over functional impairment. Patients often have symptoms such as hematuria, proteinuria, edema and hypertension.

Diagnosis of Nephritis

The diagnosis methods of nephritis are as follows:

• Urine routine. Through urine routine, urine protein, occult blood, white blood cells, bacteria, etc. can be initially observed. Observe the morphology of red blood cells under a microscope to determine whether hematuria originated from the kidneys.
• Blood routine. The blood cell count is a good indicator of infection, anemia, and clotting disorders.
• Immunological detection. Detection of serum complement C2, C4 and CH50, in addition to detection of anti-nuclear antibody spectrum, ENA polypeptide antibody spectrum, immunoglobulin, ANCA, anti-glomerular basement membrane antibody, etc.
• Renal function test. The detection of serum creatinine, endogenous creatinine clearance, and glomerular filtration can determine the degree of renal damage.
• Imaging diagnosis. Ultrasound of the urinary system can observe the size of the kidney, which helps to judge the progress of kidney disease.
• Renal biopsy. It is of great significance to the diagnosis, condition evaluation, prognosis and treatment of various renal diseases.

Advantages of Our Products

Creative Biogene's products are mainly targeted at the autoantibody detection to diagnose nephritis, and use enzyme-linked immunoassay to qualitatively and quantitatively determine the markers in human serum or plasma. Our product can quickly detect autoantibodies produced when the occurrence of nephritis, and is one of the effective methods for nephritis detection. Our detection kits will provide you with all the necessary reagents, stable and reliable performance, short detection time, high sensitivity, specificity and reproducibility.

Creative Biogene's skilled scientists have experience in developing outstanding products in the field of nephritis diagnosis. We will uphold the belief of pursuing high quality and the spirit of professionalism to provide you with our optimal products. We look forward to working with you for your cooperation.

Please contact us for more details.

Reference

1. SathickJ, et al. (2013). "Acute interstitial nephritis: etiology, pathogenesis, diagnosis, treatment and prognosis." Nephrology Reviews. 5: e4, 13-20.