Myasthenia Gravis

Myasthenia gravis (MG) is an acquired autoimmune disease. The main symptom is the weakness of skeletal muscle contraction caused by neuromuscular transmission disorders. Neuromuscular junction postsynaptic membrane acetylcholine receptor is attacked by autoantibodies. When the function of this important receptor is abnormal, it will directly affect the normal conduction and movement of the neuromuscular. At first, the patient is prone to fatigue, after activities feel more tired, and can be relieved after rest. It can be manifested as drooping eyelids, difficulty swallowing, weak speech, and even breathing difficulties. Myasthenia gravis is mainly treated with drugs, and surgery is required in some cases.

Diagnosis of Myasthenia Gravis

The diagnosis of myasthenia gravis is more complicated and needs a variety of examination methods to confirm the diagnosis. There are four commonly used tests:

• The neostigmine methyl sulfate test. The muscles with the most obvious symptoms are selected and the initial muscle strength is recorded. After that, the patient will be injected with neostigmine methyl sulfate intramuscularly and recorded every 10 minutes. The entire recording process is 1 hour. Then compare the changes in muscle strength, measure the inspection results to make a judgment.
• Repeating nerve electric stimulation (RNES). It is a commonly used inspection method. 90% of myasthenia gravis patients are positive during low-frequency stimulation, and related to the severity of the disease.
• Serum antibody test. Skeletal muscle acetylcholine receptor (AChR) antibody and serum muscle-specific kinase (MuSK) antibody are specific antibodies for the diagnosis of myasthenia gravis. The diagnosis can be confirmed by combining the patient's medical history and positive results. Anti-striated muscle antibodies also have certain diagnostic value.
• Thymic imaging examination. Among the patients, 10%-15% have thymic neoplasms, and about 80% have thymic abnormalities. Symptoms of myasthenia gravis may appear in 20%-25% of patients with thymic tumors. Therefore, some patients with thymic swelling and pruritus may also need to get an enhanced CT scan or MRI.

Advantages of Our Products

Creative Biogene's products are mainly enzyme-linked immunoassay kits developed for acetylcholine receptor antibodies, serum muscle-specific kinase antibody and other specific antibodies against myasthenia gravis. Antibody detection is necessary for the diagnosis and treatment of myasthenia gravis. Our products have excellent performance in the auxiliary diagnosis of this disease, which will help you to carry out your research smoothly.

Creative Biogene focuses on the field of diagnostic reagents for myasthenia gravis. It is sincerely looking forward to cooperating with you and providing you the best quality product with all of our hearts! We look forward to working with you for your cooperation.

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Reference

1. Díaz M, et al. (2007). "Antibodies to AChR, MuSK and VGKC in a patient with myasthenia gravis and Morvan's syndrome. " Nature Clinical Practice Neurology. 3.7:405-410.