hsa-miR-192-5p miREIA

miR-192-5p is one of the most abundant microRNAs in the kidney and targets the mRNA for ATP1B1 (β1 subunit of Na+/K+-ATPase). miR-192-5p levels were significantly lower in kidney biopsy specimens from patients with hypertension or hypertensive nephrosclerosis compared with levels in controls. This suggests miR-192-5p in the kidney could protects against the development of hypertension. Both serum and urinary miR-192 could be a potential biomarker of diabetic kidney disease (DKD), playing a crucial role in the prevention and treatment of this disease. Compared with controls, the expression of miR-192 in serum is decreased, while in urine it is increased with the progression of DKD. Regarding neuroscience, altered miR-192-5p plasma level may function as a predictive biomarker for outcome in acute ischaemic stroke patients receiving thrombolysis.