Genetic Diseases

Genetic diseases refer to diseases caused by congenital genetic abnormalities, gene mutations, or gene regulation disorders, which can be broadly divided into single-gene diseases and polygenic diseases. Common genetic diseases include sickle anemia, albinism, hemophilia and so on. In addition, cancer also belongs to the category of genetic diseases, and gene mutations are closely related to cancer. Cancer is caused by damage to the DNA in cells, and these changes are called gene mutations. Over time, mutations accumulate in cells in the body. Cells with too many mutations may stop working normally, grow out of control, and become cancer cells. Gene mutations that accumulate in cells are called "acquired" or "somatic" mutations. Aging, exposure to hormones, environmental toxins, and certain viruses can cause mutations. Except for a few tumors, such as familial colonic polyposis, neurofibroma, and malignant melanoma, which belong to single-cell genetic diseases, the vast majority of tumors belong to the category of polygenic diseases. A variety of genes are involved, including proto-oncogenes, tumor suppressor genes, apoptosis regulatory genes, and changes in DNA repair genes.

Diagnosis of Genetic Diseases

The mechanism of genetic diseases is very complicated. For patients with different genetic diseases, the molecular mechanisms and histopathological pathways leading to the pathogenesis are different. With the continuous deepening of research at the molecular level of genes, more and more disease signal pathways have been discovered. Clinically, the detection of the amplification, mutation and expression of specific genes in these pathways helps to detect diseases. Gene diagnosis is a method to diagnose diseases by using modern molecular biology and molecular genetics techniques, such as fluorescence PCR and PCR probe, to directly detect whether gene structure and expression level are normal. The detection target of genetic diagnosis is DNA or RNA. The former reflects the existence status of genes, and the latter reflects the expression status of genes.

Advantages of Our Products

Creative Biogene's test kit is mainly used for qualitative detection of gene mutations caused by human non-small cell lung cancer, colorectal cancer, breast cancer, glioma, hepatitis B and other genetic diseases. Our products are simple and convenient to operate, and have excellent performance in sensitivity, specificity and accuracy, which can help you to carry out related research smoothly.

Creative Biogene's skilled scientists have extensive experience in developing diagnostic products for genetic diseases. It is sincerely looking forward to cooperating with you and providing you with the best quality product with all our hearts! You can choose us without hesitation.

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Reference

1. Todorova R. (2011). "Comparative analysis of the methods of drug and protein delivery for the treatment of cancer, genetic diseases and diagnostics." Drug Delivery. 18.8:586-598.