Urinary trypsin inhibitor human ELISA kit

Urine trypsin inhibitor (UTI) is an acid glycoprotein produced by the endoplasmic reticulum of liver cells. As a precursor, UTI is linked to 1-microglobulin. According to reports, the concentration of free, uncomplicated UTI in the plasma of patients with inflammation is higher than normal. Under severe inflammatory conditions, plasma UTI levels and gene expression change. In patients with various kidney diseases, a clear correlation between UTI and the concentration of creatinine in plasma was found, which means that the kidney is the main site for ingesting this protein. UTI is quickly released into the urine when infection occurs. It is an excellent inflammatory marker and constitutes most of the antitrypsin activity in urine. UTI levels in urine may increase under various pathological conditions, including pneumonia, emphysema, rheumatoid arthritis, cancer, and surgical trauma. In vitro studies have shown that serine protease inhibitors may have anti-inflammatory effects. UTI inhibits the infiltration of neutrophils and inhibits the release of elastase and chemical mediators from neutrophils. Clinically, UTI is widely used to treat acute inflammatory diseases such as pancreatitis, shock and diffuse intravascular coagulation.