TGFB2 polyclonal antibody

This gene encodes a member of the transforming growth factor β (TGFB) cytokine family, a multifunctional peptide that regulates proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing signals through transmembrane receptors type I and II Type combination (TGFBR1 and TGFBR2) and its downstream effector, SMAD protein. Disruption of the TGFB/SMAD pathway is associated with a variety of human cancers. The encoded protein secretes and inhibits the growth of interleukin-2 dependent t cells. The t(1, 7)(q41, p21) shift between this gene and HDAC9 is related to Peters abnormality, which is a congenital defect of the anterior chamber of the eye. Knockout mice lacking this gene show perinatal mortality and a series of developmental defects, including heart defects.