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SerpinA1 ELISA Kit

  • Product Information
  • Description
Catalog: C-EL-1894T
Product Type: Test kit
Size: 96 tests
Principle: Solid Phase Sandwich ELISA
Conjugation: HRP
Species: Human
Detection range: 62.5-4000 pg/mL
Sensitivity: 26.37 pg/mL
Specificity: Recognizes both recombinant and natural Human SerpinA1
Sample type: Serum
Test type: Quantitative
Analysis mode: ELISA
Shipping: This ELISA Kit is shipped at ambient temperature.
Storage: 2-8℃
Full name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

This SerpinA1 ELISA Kit, Human is an enzyme-linked immunosorbent assay for the quantitative measurement of Human SerpinA1 protein in Serum . It contains recombinant Human SerpinA1, and antibodies raised against the recombinant protein. This ELISA kit is complete and ready-to-use.SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antitrypsin is mainly produced in the liver and acts as an antiprotease. Its principal function is to inactivate neutrophil elastase, preventing tissue damage. SerpinA1 (alpha1-antitrypsin), an acute phase protein and the classical neutrophil elastase inhibitor, is localized within lipid rafts in primary human monocytes in vitro. Its association with monocytes is inhibited by cholesterol depleting/efflux-stimulating agents (nystatin, filipin, MbetaCD (methyl-beta-cyclodextrin) and oxidized low-density lipoprotein (oxLDL) and conversely, enhanced by free cholesterol. Furthermore, SerpinA1/monocyte association per se depletes lipid raft cholesterol as characterized by the activation of extracellular signal-regulated kinase 2, formation of cytosolic lipid droplets, and complete inhibition of oxLDL uptake by monocytes. Previous population studies have suggested that heterozygote status for the AAT gene (SerpinA1) is a risk factor for chronic rhinosinusitis with nasal polyposis (CRSwNP). Alpha-1 antitrypsin deficiency is a recently identified genetic disease that occurs almost as frequently as cystic fibrosis. It is caused by various mutations in the SerpinA1 gene, and has numerous clinical implications. Alpha-1 antitrypsin deficiency is an inherited disease affecting the lung and liver. In the liver, alpha-1 antitrypsin deficiency may manifest as benign neonatal hepatitis syndrome; a small percentage of adults develop liver fibrosis, with progression to cirrhosis and hepatocellular carcinoma. Its most important physiologic functions are the protection of pulmonary tissue from aggressive proteolytic enzymes and regulation of pulmonary immune processes.

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