Sepsis assay kit

HBP is released from secretory vesicles of activated neutrophils in contact with endothelial cells. Once released, it induces calcium-dependent rearrangement of the endothelial cell cytoskeleton, leading to cell contraction and increasing endothelial permeability. It is also internalized by endothelial cells to protect it from apoptosis. At the site of infection, HBP is also secreted by nitrourea particles during phagocytosis, where it exhibits antibacterial activity and is responsible for the recruitment and activation of monocytes and other inflammatory mediators. It is also internalized by monocytes to prolong survival and enhance cytokine production. Therefore, HBP directly contributes to the maintenance and progression of inflammation, and the measurement of HBP can be used to identify patients at risk of developing sepsis with circulatory failure upon admission to the emergency department.