RUNX1T1 polyclonal antibody

This gene encodes a member of the myeloid translocation gene family that interacts with DNA-bound transcription factors and recruits a series of co-repressor factors to promote transcriptional inhibition. t(8;21)(q22;q22) translocation is one of the most common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene, which is formed by fusing the 5'-region of the runt-related transcription factor 1 gene with the 3'-region of the gene. The chimeric protein is believed to bind to the nuclear co-inhibitor/histone deacetylase complex, thereby hindering hematopoietic differentiation.