Rheumatoid Factor IgG / IgA / IgM ELISA

Rheumatoid factor screening ELISA is a solid-phase enzyme immunoassay with high-purity human immunoglobulin (IgG) Fc fragments for the combined quantitative detection of IgG, IgM and IgA rheumatoid factors (RF) in human serum. This assay is helpful in the diagnosis of rheumatoid arthritis (RA). The diseases commonly associated with high RF concentrations are rheumatoid arthritis and Sjögren's syndrome. They are also present in systemic lupus erythematosus, systemic sclerosis, polymyositis/dermatomyopathies, ice globulinemia, and mixed connective tissue disease. Although the presence of IgM RF in serum has been regarded as the most important serological indicator of RA, and therefore has been included in the standard list of ACR to diagnose the disease, the RF and IgA subclasses of IgG are also important for diagnosis. . All three subcategories can be found in SLE. In particular, the IgA subclass defines a subgroup of SLE patients, which is characterized by unique autoimmune phenomena and high disease activity in the absence of nephritis