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| Catalog: | C-FC-4335A |
| Product Type: | FCM Antibody |
| Size: | 25 Tests/100 Tests |
| Concentration: | 2 μl/Test, 0.1 mg/ml |
| Reactivity: | Human |
| Specificity: | Human TNF-alpha |
| Analysis mode: | FCM |
| Host: | Rabbit |
| Clonality: | Monoclonal |
| Isotype: | IgG |
| Alternate names: | tumor necrosis factor |
| Form: | Liquid |
| Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Purification method: | Protein A |
| Conjugation: | PE |
| Immunogen: | Recombinant Human TNF-alpha / TNFA Protein |
| Buffer: | Aqueous solution containing 0.5% BSA and 0.09% sodium azide |
| Application: | Cancer Drug Targets; Neuroinflammation |
Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment.
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