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| Catalog: | C-FC-4326A |
| Product Type: | FCM Antibody |
| Size: | 25 Tests/100 Tests |
| Concentration: | 10 μl/Test, 0.1 mg/ml |
| Reactivity: | Human |
| Specificity: | Human TIE2 |
| Analysis mode: | FCM |
| Host: | Rabbit |
| Clonality: | Monoclonal |
| Isotype: | IgG |
| Alternate names: | TEK tyrosine kinase, endothelial |
| Form: | Liquid |
| Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Purification method: | Protein A |
| Conjugation: | FITC |
| Immunogen: | Recombinant Human Tie2 / CD202b / TEK protein |
| Buffer: | Aqueous solution containing 0.5% BSA and 0.09% sodium azide |
| Application: | Receptor Tyrosine Kinases (RTKs); Cancer Drug Targets; Hemangioblast Markers |
TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
Core Diagnostic Capabilities
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