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| Catalog: | C-FC-4195A |
| Product Type: | FCM Antibody |
| Size: | 50 µL/100 µL |
| Reactivity: | Human |
| Specificity: | Human LILRA3 |
| Analysis mode: | FCM |
| Host: | Rabbit |
| Clonality: | Monoclonal |
| Isotype: | IgG |
| Alternate names: | leukocyte immunoglobulin like receptor A3 |
| Form: | Liquid |
| Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage: | This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles. |
| Purification method: | Protein A |
| Conjugation: | Unconjugated |
| Immunogen: | Recombinant Human LILRA3/CD85e/ILT6 Protein |
| Buffer: | 0.2 μm filtered solution in PBS |
| Application: | ITIM/ITAM Immunoreceptors and Related Molecules |
ILT6, also known as LILRA3, belongs to the ILT family. In humans, the ILT gene family includes up to 11 members. The extracellular portion of all members includes at least two and usually four immunoglobulin domains. ILT-2 through 5 are all inhibitory members having variable numbers of cytoplasmic ITIM domains. ILT6 lacks a transmembrane domain. The function of ILT6 is currently unknown. however it is highly homologous to other LILR genes, and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the ILT6 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.
Core Diagnostic Capabilities
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