Catalog: | C-FC-3777A |
Product Type: | FCM Antibody |
Size: | 25 Tests/100 Tests |
Concentration: | 10 μl/Test, 0.1 mg/ml |
Reactivity: | Human |
Specificity: | Human CD28 |
Analysis mode: | FCM |
Host: | Rabbit |
Clonality: | Monoclonal |
Isotype: | IgG |
Alternate names: | CD28 molecule |
Form: | Liquid |
Shipping: | This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Storage: | This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
Purification method: | Protein A |
Conjugation: | PerCP |
Immunogen: | Recombinant Human CD28/TP44 Protein |
Buffer: | Aqueous solution containing 0.5% BSA and 0.09% sodium azide |
Application: | ITIM/ITAM Immunoreceptors and Related Molecules; Cancer Drug Targets |
CD28 (Cluster of Differentiation 28) is a disulphide-bonded glycoprotein belonging to the immunoglobulin (Ig) superfamily, and structurally consists of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. Mouse CD28 is constitutively expressed on the surface of all murine T cells and on developing thymocytes as disulfide-linked homodimers or as monomers. CD28 can binds the B7-1 and B7-2 ligand, and together perform important functions in the T and B cell response pathways. B7/CD28 family members, which can augment or antagonize T-cell receptor signaling, in the regulation of central and peripheral T-cell tolerance. CD28 is thus involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
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