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| Catalog: | C0073A |
| Product Type: | Antibody |
| Reactivity: | H,M,R |
| Analysis mode: | WB,ELISA |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 0.5 mg/mL |
| Storage: | -20℃ |
| Buffer: | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Purification method: | Antigen affinity purification |
| Application: | Cancer, Cell Biology, Signal Transduction |
| Conjugation: | Unconjugated |
| Immunogen: | GNB2L1 |
| Swiss port: | P63244 |
| Gene accession: | BC000214 |
| Celluar localization: | Cell membrane. Located on plasma membrane of neuroblastoma NMB7 cells. |
| Tissue specificity: | In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue. |
RACK1 is also known as Human lung cancer Oncogene 7 protein. RACK1 acts as a rack to inhibit Src tyrosine kinase activity. In response to PKC activation, intracellular localization of RACK1 and PKC bII changes, and RACK1 and PKC bII co-locate to the same site.Therefore, RACK1 is considered to be the shuttle protein of PKC bII. The absence of RACK1 may be associated with impaired PKC activation in the aging brain.
Diagnostic Development
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