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Purified Anti-Mouse/Human CD44 Antibody

  • Product Information
  • Description
Catalog: C-FC-2776A
Product Type: FCM Antibody
Size: 50 μg/100 μg
Reactivity: Mouse/Human
Analysis mode: FCM,IHC,IP
Host: Rat
Isotype: Rat IgG2b, κ
Alternate names: CD44 antigen,CD44,CDw44,Epican,Phagocytic glycoprotein 1,PGP-1,Phagocytic glycoprotein I,PGP-I,CD44,LHR, MDU2, MDU3, MIC4
Form: Liquid
Shipping: Biological ice pack at 4℃
Storage: 2-8℃
Conjugation: Unconjugated
Buffer: PBS with 0.05% Proclin300
Swiss port: P15379,P16070
Clone NO.: IM7
Recommended use: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 μg per 106 cells in 100 μL volume or 100 μL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

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