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Purified Anti-Mouse CD54 Antibody

  • Product Information
  • Description
Catalog: C-FC-2752A
Product Type: FCM Antibody
Size: 50 μg/100 μg
Reactivity: Mouse
Analysis mode: FCM,WB,IHC,IP
Host: Rat
Isotype: Rat IgG2b, κ
Alternate names: Intercellular adhesion molecule 1,Icam1,MALA-2,MyD10,CD54,Icam-1
Form: Liquid
Shipping: Biological ice pack at 4℃
Storage: 2-8℃
Conjugation: Unconjugated
Buffer: PBS with 0.05% Proclin300
Swiss port: P13597
Clone NO.: YN1/1.7.4
Recommended use: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 μg per 106 cells in 100 μL volume or 100 μL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.

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