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PE/Cyanine7 Anti-Mouse CD206 Antibody

  • Product Information
  • Description
Catalog: C-FC-2186A
Product Type: FCM Antibody
Size: 25μg/50μg/100μg
Reactivity: Mouse
Analysis mode: ICFCM
Host: Rat
Isotype: Rat IgG2a, κ
Alternate names: MMR,MR,MRC1,macrophage mannose receptor,mannose receptor
Form: Liquid
Shipping: Biological ice pack at 4℃
Storage: 2-8℃
Conjugation: PE/Cyanine7
Buffer: PBS with 0.05% Proclin300, 1% BSA
Swiss port: Q61830
Clone NO.: C068C2
Recommended use: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results or refer to the dilution we used in the experiment.

CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

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