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PE/Cyanine7 Anti-Mouse CD200 Antibody

  • Product Information
  • Description
Catalog: C-FC-2184A
Product Type: FCM Antibody
Size: 25 μg/50 μg/100 μg/200 μg
Reactivity: Mouse
Analysis mode: FCM
Host: Rat
Isotype: Rat IgG2a, κ
Alternate names: OX-2 membrane glycoprotein,OX-2, MRC
Form: Liquid
Shipping: Biological ice pack at 4℃
Storage: 2-8℃
Conjugation: PE/Cyanine7
Buffer: PBS with 0.05% Proclin300, 1% BSA
Swiss port: O54901
Clone NO.: OX-90
Recommended use: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results or refer to the dilution we used in the experiment.

CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R). The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.

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