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| Catalog: | C-FC-1859A |
| Product Type: | FCM Antibody |
| Size: | 20 tests/50 tests/100 tests/500 tests |
| Reactivity: | Rat |
| Analysis mode: | FCM |
| Host: | Mouse |
| Isotype: | Mouse IgG2a, κ |
| Alternate names: | Pgp-1, H-CAM, CD44s,CD44H |
| Form: | Liquid |
| Shipping: | Biological ice pack at 4℃ |
| Storage: | 2-8℃ |
| Conjugation: | PE/Cyanine5 |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Swiss port: | Q63961 |
| Clone NO.: | OX-49 |
| Recommended use: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
CD44 is an 80-95 kD cell surface glycoprotein. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It is up-regulated when T cells and B cells are activated. It was reported that CD44 is a valuable marker for memory T cells. CD44 is an adhesion molecule involved in leukocyte adhesion and homing to lymphoid organs. The OX-49 antibody reacts with CD44H (known as CD44s) expressed on most leukocytes, except for a subset of B lymphocytes. The epitope recognized by OX-49 antibody has been mapped to a region on both the standard, CD44s, and the splice variant, CD44v, isoforms of CD44. However it was reported that OX-49 antibody cannot detect the CD44V isoform, possibly due to conformational changes in the epitope.
Core Diagnostic Capabilities
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