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| Catalog: | C-FC-2001A |
| Product Type: | FCM Antibody |
| Size: | 50 tests/100 tests/200 tests/500 tests |
| Reactivity: | Mouse |
| Analysis mode: | FCM |
| Host: | Rat |
| Isotype: | Rat IgG2b, κ |
| Alternate names: | Intercellular adhesion molecule 1,Icam1,MALA-2,MyD10,CD54,Icam-1 |
| Form: | Liquid |
| Shipping: | Biological ice pack at 4℃ |
| Storage: | 2-8℃ |
| Conjugation: | PE/Cyanine5.5 |
| Buffer: | PBS with 0.05% Proclin300, 1% BSA |
| Swiss port: | P13597 |
| Clone NO.: | YN1/1.7.4 |
| Recommended use: | Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. |
CD54 is a 90 kD immunoglobulin superfamily member also known as ICAM-1 and Ly-47. It is expressed on activated endothelial cells, high endothelial venules (HEV), T and B cells, monocytes/ macrophages, granulocytes, and dendritic cells. CD54 is an important intracellular adhesion molecule that participates in T cell-T cell, T cell-B cell, and T cell-target cell interactions via binding of LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). CD54 has also been shown to be involved in lymphocyte trafficking, making it an important molecule in many immune reactions and inflammation. CD54 is also a receptor for rhinovirus. The YN1/1.7.4 antibody has been reported to block binding of mouse CD54 to LFA-1 and Mac-1, inhibit cell-cell adhesion, and function in antigen presentation to T cells and leukocyte migration to inflammatory tissues.
Core Diagnostic Capabilities
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