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| Catalog: | C-FC-4884A |
| Product Type: | FCM Antibody |
| Size: | 0.2 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | human peripheral blood lymphocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 μl per 10^6 cells in a 100 µl suspension or 5 μl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | IgG2a |
| Alternate names: | Klrb1a, Ly55a, NKR P1A, Nkrp1 a, NKRP12, Nkrp1a |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | NK-1+ cells from mouse spleen and bone marrow |
| Genn_ID: | 29126 |
| Gene accession: | BC069381 |
| Gene symbol: | CD274 |
| Buffer: | Phosphate based buffer with 0.09% sodium azide and 0.1% gelatin, pH 7.2. |
NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665).
Core Diagnostic Capabilities
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