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| Catalog: | C-FC-4874A |
| Product Type: | FCM Antibody |
| Size: | 0.1 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | BALB/c mouse splenocytes |
| Recommended dilution: | IF : 1:250-1:1000 This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgG2a |
| Alternate names: | BB154331, CD8 antigen, alpha chain, Cd8a, Ly 2, Ly 35, Ly B, Lyt 2 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Spleen cells or thymocyte membranes |
| Genn_ID: | 12525 |
| Gene accession: | BC030679 |
| Gene symbol: | Cd8a |
| Buffer: | PBS with 0.1% sodium azide and a stabilizer. |
CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084).
Core Diagnostic Capabilities
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