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| Catalog: | C-FC-4873A |
| Product Type: | FCM Antibody |
| Size: | 0.1 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgG2a |
| Alternate names: | B7, B7 2, B7.2, B70, Cd28l2, Cd86, CD86 antigen, CLS1, ETC 1, Ly 58, Ly58, MB7, MB7 2, TS/A 2 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | LPS-activated CBA/Ca mouse spleen B cells |
| Genn_ID: | 12524 |
| Gene accession: | BC013807 |
| Gene symbol: | Cd86 |
| Buffer: | PBS with 0.1% sodium azide and a stabilizer. |
CD86 (also known as B7-2) is a costimulatory molecule belonging to the immunoglobulin superfamily. Primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, and macrophages, CD86 is the ligand for two proteins at the cell surface of T cells, CD28 antigen and CTLA-4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with CTLA-4 negatively regulates T-cell activation and diminishes the immune response. (PMID: 7513726; 1847722; 11029388; 27591335)
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