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| Catalog: | C-FC-4871A |
| Product Type: | FCM Antibody |
| Size: | 0.2 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | Daudi cells |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Armenian Hamster |
| Isotype: | IgG |
| Alternate names: | B7 1, B7.1, Cd28l, Cd80, CD80 antigen, Ly 53, Ly53, MIC17, TS/A 1 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | CHO cell line transfected with mouse B7 (CD80) |
| Genn_ID: | 941 |
| Gene accession: | BC042665 |
| Gene symbol: | CD80 |
| Buffer: | Phosphate based buffer with 0.09% sodium azide and 0.1% gelatin, pH 7.2. |
CD80 (also known as B7-1) is a type I membrane protein that is a member of the immunoglobulin superfamily, with an extracellular immunoglobulin constant-like domain and a variable-like domain required for receptor binding. It is expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, monocytes, and macrophages. CD80 is the receptor for the proteins CD28 and CTLA-4 found on the surface of T-cells. It is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. CD80 also acts as a cellular attachment receptor for adenovirus subgroup B. (PMID: 7545666; 12015893; 16920215)
Core Diagnostic Capabilities
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