Catalog: | C-FC-4860A |
Product Type: | FCM Antibody |
Size: | 0.1 mg/ml |
Reactivity: | Mouse |
Positive FC: | BALB/c mouse splenocytes |
Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
Analysis mode: | FC |
Host: | Rat |
Isotype: | IgG2a |
Alternate names: | AI326936, Bp50, Cd40, CD40 antigen, GP39, HIGM1, IGM, IMD3, p50, T BAM, Tnfrsf5, TRAP |
Storage: | 2-8°C |
Purification method: | Affinity purification |
Immunogen: | sCD40 |
Genn_ID: | 21939 |
Gene accession: | BC029254 |
Gene symbol: | Cd40 |
Buffer: | PBS with 0.1% sodium azide and a stabilizer. |
CD40, also named as TNFRSF5 and Bp50, is a type I transmembrane protein that belongs to the tumor necrosis factor-R (TNF-R) family (PMID: 10647992). CD40 is expressed on B cells, dendritic cells (DCs), monocytes, platelets, and macrophages as well as by non-hematopoietic cells such as myofibroblasts, fibroblasts, epithelial, and endothelial cells (PMID: 19426221). It is a receptor for TNFSF5/CD40LG. CD40L/CD40 interactions are essential for immunoglobulin (Ig) isotype switching, germinal center formation and the development of B cell memory (PMID: 7516405; 11675497).
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