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| Catalog: | C-FC-4854A |
| Product Type: | FCM Antibody |
| Size: | 0.1 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | mouse splenocytes |
| Recommended dilution: | IF : 1:50-1:500 This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl per 10^6 cells in a 100 µl suspension or 5 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgG2a |
| Alternate names: | C85791, Cd31, Pecam, PECAM 1, Pecam1 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | C3H/HeJ mouse hematopoietic progenitor cell line 32D |
| Genn_ID: | 18613 |
| Gene accession: | BC008519 |
| Gene symbol: | Pecam1 |
| Buffer: | PBS with 0.1% sodium azide and a stabilizer. |
Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489).
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