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| Catalog: | C-FC-4852A |
| Product Type: | FCM Antibody |
| Size: | 0.2 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | Human peripheral blood lymphocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 µl(1µg) per 10^6 cells in a 100 µl suspension or 5 µl(1µg) per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgG2b |
| Alternate names: | AI504783, CD3, Cd3e, CD3epsilon, T3e |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | γδTCR-positive T-T hybridoma D1 |
| Genn_ID: | 916 |
| Gene accession: | BC049847 |
| Gene symbol: | CD3E |
| Buffer: | Phosphate based buffer with 0.09% sodium azide and 0.1% gelatin, pH 7.2. |
CD3 is a multimeric protein associated with the T-cell receptor (TCR) to form a complex involved in antigen recognition and signal transduction (PMID: 15885124). CD3 is composed of CD3γ, δ, ε, and ζ chains (PMID: 1826255). It is expressed by thymocytes in a developmentally regulated manner, T cells, and some NK cells (PMID: 3289580). The TCR recognizes antigens bound to major histocompatibility complex (MHC) molecules. TCR-mediated peptide-MHC recognition is transmitted to the CD3 complex, leading to the intracellular signal transduction (PMID: 11985657).
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