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| Catalog: | C-FC-4849A |
| Product Type: | FCM Antibody |
| Size: | 0.2 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | human peripheral blood mononuclear cells cells |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgG2a |
| Alternate names: | AU044799, B7 H2, B7h, B7RP 1, BG071784, GI50, GL50, GL50 B, ICOS L, icos ligand, Icosl, Icoslg, KIAA0653, LICOS, Ly115l, mKIAA0653 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Mouse B7-RP1 transfected cell line |
| Genn_ID: | 5133 |
| Gene accession: | BC074740 |
| Gene symbol: | PDCD1 |
| Buffer: | Phosphate based buffer with 0.09% sodium azide and 0.1% gelatin, pH 7.2. |
B7-H2, also known as CD275, B7RP-1 or ICOSL, is a co-stimulatory molecule of the B7 superfamily (PMID: 11023515). It is expressed on lymphoid cells such as B cells, monocytes/macrophages and dendritic cells and is also induced on nonlymphoid tissue cells, such as endothelial cells, epithelial cells and muscle cells (PMID: 16499572). B7-H2 binds to ICOS which is expressed on activated T cells and resting memory T cells (PMID: 10617205). The interaction of ICOS/B7-H2 plays an important role in the T cell costimulation pathway.
Core Diagnostic Capabilities
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