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| Catalog: | C-FC-4837A |
| Product Type: | FCM Antibody |
| Size: | 0.1 mg/ml |
| Reactivity: | Mouse |
| Positive FC: | mouse bone marrow cells |
| Recommended dilution: | This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. |
| Analysis mode: | FC |
| Host: | Rat |
| Isotype: | IgG2b |
| Alternate names: | Bs, c KIT, CD117, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, Kit, kit oncogene, SCO1, SCO5, SOW3, Ssm, Tr kit |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Mouse IL-3-dependent bone marrow mast cells |
| Genn_ID: | 16590 |
| Gene accession: | BC052457 |
| Gene symbol: | Kit |
| Buffer: | PBS with 0.1% sodium azide and a stabilizer. |
CD117, also known as c-Kit and SCFR, is a transmembrane protein with tyrosine kinase activity encoded by the oncogene c-kit (PMID: 2448137). It is a member of the type III receptor tyrosine kinase family, which also includes CSF-1R, PDGFRβ, PDGFRα, and FLT3 (PMID: 29518044). CD117 is expressed on hematopoietic stem cells and progenitor cells, mast cells, and is also found in a wide range of non-haemopoietic cell types (including melanocytes, germ cells, astrocytes, renal tubules, breast glandular epithelial cells, sweat glands, and interstitial cells of Cajal) (PMID: 10582338; 23073628). CD117 plays an important role in early haemopoiesis. It is also involved in pigmentation, fertility, gut movement, and some aspects of the nervous system (PMID: 23073628).
Core Diagnostic Capabilities
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