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| Catalog: | C-FC-4831A |
| Product Type: | FCM Antibody |
| Size: | 10 µl/test |
| Reactivity: | Human |
| Positive FC: | Human peripheral blood lymphocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | IgG1 |
| Alternate names: | ALPS1A, APO 1, Apo 1 antigen, APT1, CD95, FAS, FAS1, FASLG receptor, FASTM, TNFRSF6 |
| Storage: | 2-8°C |
| Purification method: | Affinity purification |
| Immunogen: | Human CD95 transfected L cells |
| Genn_ID: | 355 |
| Gene accession: | BC012479 |
| Gene symbol: | FAS |
| Buffer: | PBS with 0.1% sodium azide and a stabilizer. |
Fas (CD95/APO-1) is a transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily. It can mediates apoptosis by ligation with an agonistic anti-Fas antibody or Fas ligand. Stimulation of Fas results in the aggregation of its intracellular death domains, leading to the formation of the death-inducing signaling complex (DISC). FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
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