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| Catalog: | C-FC-4827A |
| Product Type: | FCM Antibody |
| Size: | 20 µl/test |
| Reactivity: | Human |
| Positive FC: | human peripheral blood monocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 μl per 10^6 cells in a 100 µl suspension or 5 μl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Alternate names: | Activation B7 2 antigen, B7 2, B70, BU63, CD28LG2, CD86, CD86 molecule, CTLA 4 counter receptor B7.2, FUN 1, LAB72 |
| Storage: | 2-8°C |
| Purification method: | The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Immunogen: | B-lymphoblastoid cell line ARH 77 |
| Genn_ID: | 942 |
| Gene accession: | BC040261 |
| Gene symbol: | CD86 |
| Buffer: | PBS with 0.1% sodium azide. |
CD86 (also known as B7.2) is a costimulatory molecule belonging to the immunoglobulin superfamily. Primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, and macrophages, CD86 is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response.
Core Diagnostic Capabilities
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