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PE Anti-Human CD44 (F10-44-2)

  • Product Information
  • Description
Catalog: C-FC-4811A
Product Type: FCM Antibody
Size: 10 µl/test
Reactivity: Human
Positive FC: Human peripheral blood lymphocytes
Recommended dilution: This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood.
Analysis mode: FC
Host: Mouse
Isotype: IgG2a
Alternate names: CD44, CD44 antigen, CDW44, CSPG8, ECMR III, Epican, HCELL, Heparan sulfate proteoglycan, Hermes antigen, HUTCH I, Hyaluronate receptor, IN, LHR, MC56, MDU2, MDU3, MIC4, MUTCH I, PGP 1, PGP I, Pgp1, Phagocytic glycoprotein 1, Phagocytic glycoprotein I
Storage: 2-8°C
Purification method: Affinity purification
Immunogen: Purified T cells from human lymph nodes
Genn_ID: 960
Gene accession: BC004372
Gene symbol: CD44
Buffer: PBS with 0.1% sodium azide and a stabilizer.

CD44 is a type I transmembrane glycoprotein expressed on embryonic stem cells and in various levels on other cell types including connective tissues and bone marrow. CD44 expression is also upregulated in subpopulations of cancer cells and is recognized as a molecular marker for cancer stem cells (PMID: 29747682). It is a cell-surface receptor that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands (PMID: 10694938). Adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis.

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