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| Catalog: | C-FC-4810A |
| Product Type: | FCM Antibody |
| Size: | 10 µl/test |
| Reactivity: | Human |
| Positive FC: | Human peripheral blood lymphocytes |
| Recommended dilution: | This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 10 µl per 10^6 cells in a 100 µl suspension or 10 µl per 100 µl of whole blood. |
| Analysis mode: | FC |
| Host: | Mouse |
| Isotype: | Mouse IgG1 |
| Alternate names: | BSS, CD42B, CD42b alpha, GP1B, GP1BA, GPIb alpha, GPIbα |
| Storage: | 2-8°C |
| Purification method: | The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography. |
| Immunogen: | Human platelets |
| Genn_ID: | 960 |
| Gene accession: | BC004372 |
| Gene symbol: | CD44 |
| Buffer: | PBS with 0.1% sodium azide. |
CD42b, also known as platelet glycoprotein Ib alpha chain (GPIb alpha), is a type I transmembrane glycoprotein of 135-145 kDa (PMID: 2656709). It is expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are linked by a disulphide bond to form GPIb (PMID: 7660135). GPIb forms a noncovalent complex with CD42a (GPIX) and CD42d (GPV) and acts as a receptor for von Willebrand factor (vWF) and thrombin (PMID: 7660135; 3759960). The GPIb-V-IX complex mediates vWF-dependent platelet adhesion to blood vessels. Defects in the expression of CD42b result in Bernard-Soulier syndromes and platelet-type von Willebrand disease (PMID: 9371310).
Core Diagnostic Capabilities
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