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| Catalog: | C0049A |
| Product Type: | Antibody |
| Reactivity: | R |
| Analysis mode: | IHC |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 0.83 mg/mL |
| Storage: | -20℃ |
| Buffer: | PBS with 0.05% Proclin300 and 50% glycerol, pH7.4 |
| Purification method: | Antigen affinity purification |
| Application: | Cancer, Cardiovascular, Metabolism, Developmental Biology, Signal Transduction |
| Conjugation: | Unconjugated |
| Immunogen: | PDGFB |
| Swiss port: | Q05028 |
| Genn_ID: | 24628 |
| Celluar localization: | Endoplasmic reticulum, endoplasmic reticulum lumen, extracellular region or secreted, extracellular matrix, extracellular region, extracellular space, Golgi apparatus, Golgi lumen, Golgi membrane, plasma membrane, basolateral plasma membrane |
| Tissue specificity: | Expressed in a distinct subpopulation of smooth muscle cells in injured arteries. |
The protein encoded by the gene is a member of the platelet-derived growth factor family. The mutation has been linked to meningiomas. The reciprocal translocation between chromosomes 22 and 7, where the gene and that for COL1A1 are located, are associated with a particular type of skin tumor, called dermal fibrosarcoma, caused by unregulated expression of growth factors.
Diagnostic Development
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