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| Catalog: | C0049A |
| Product Type: | Antibody |
| Reactivity: | R |
| Analysis mode: | IHC |
| Host: | Rabbit |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Concentration: | 0.83 mg/mL |
| Storage: | -20℃ |
| Buffer: | PBS with 0.05% Proclin300 and 50% glycerol, pH7.4 |
| Purification method: | Antigen affinity purification |
| Application: | Cancer, Cardiovascular, Metabolism, Developmental Biology, Signal Transduction |
| Conjugation: | Unconjugated |
| Immunogen: | PDGFB |
| Swiss port: | Q05028 |
| Genn_ID: | 24628 |
| Celluar localization: | Endoplasmic reticulum, Endoplasmic reticulum lumen, Extracellular region or secreted, Extracellular matrix, Extracellular region,extracellular space, Golgi apparatus, Golgi lumen, Golgi membrane, Plasma Membrane, Basolateral plasma membrane |
| Tissue specificity: | Expressed in a distinct subpopulation of smooth muscle cells in injured arteries. |
The protein encoded by the gene is a member of the platelet-derived growth factor family. Four members of this family are mesenchymal-derived cell mitotic factors, and are characterized by eight cysteine motifs. The gene product can be present either as a homodimer (PDGF-BB) or as a heterodimer with platelet-derived growth factor - polypeptide (PDGF-AB), where the dimer is connected by a disulfide bond. The mutation has been linked to meningiomas. The reciprocal translocation between chromosomes 22 and 7, where the gene and COL1A1 are located, is associated with a particular type of skin tumor, called dermal fibrosarcoma, caused by unregulated expression of growth factors.
Diagnostic Development
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