p16 polyclonal antibody

CDKN2A (melanoma p16 inhibits CDK4) produces several transcript variants, and their first exon is different. At least three alternative splicing variants encoding different proteins have been reported, two of which encode structurally related subtypes and are known to act as inhibitors of CDK4 kinase. The remaining transcript includes a spare first exon 20 kb upstream of the remaining gene; this transcript contains an alternative open reading frame (ARF), which specifies a protein that is structurally unrelated to the products of other variants. This ARF product is a stabilizer of the tumor suppressor protein p53 because it can interact with and isolate the E3 ubiquitin protein ligase MDM2, which is a protein responsible for degrading p53.