NT-proANP human, sheep polyclonal antibody

NT-pro ANP (n-terminal pro-atrial natriuretic peptide) is the n-terminal polypeptide of ANP precursor. ANP is secreted by the atria under the stimulation of atrial dilation due to the increase in blood volume and/or the increase in intra-atrial pressure. ANP is a cyclic peptide that mainly acts on the kidneys and blood vessels. It can produce strong natriuresis, dilate blood vessels, and lower blood pressure. ANP, BNP and CNP together form a family of natriuretic peptides. Plasma ANP disappears rapidly due to binding to receptors and so-called scavenging receptors, making accurate measurement difficult. On the other hand, NT-pro ANP does not bind to the clearance receptor and has a long half-life, which is a good marker of ANP secretion.