MAGEL2 polyclonal antibody

Prader-Willi syndrome (Prader-Willi syndrome, PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13. Affected individuals show neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN) is a gene involved in neuronal terminal differentiation, located in this region of the genome, and is considered to be one of the genes that cause the pathogenesis of PWS. The gene is similar in structure to NDN, is also located in the PWS chromosome region, and has paternal imprinting, suggesting that it may play a role in PWS.